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  • 22 April 2016: InnovCrete Seminar » Drug Design via XRPD: From a protein microcrystalline sample to experimental powder diffraction data and the derived structural model, IMBB-FORTH, Heraklion, Crete

  • Prof. Irene Margiolaki, Patras University, GREECE
    Friday, April 22nd, 2016 @ 13:00
    FORTH Amphitheatre
    Host: M. Kokkinidis

    The development of the X-ray powder diffraction (XRPD) methods and algorithms, has already allowed for the structural characterization of a range of proteins and has been established by our group as a useful complementary technique to the traditional single crystal diffraction techniques. Protein polycrystalline samples consist of a large number of randomly oriented microcrystals. They often form in a short period of time and under different conditions of physico - chemical environment. To date, our studies on Urate Oxidase and complexes of human insulin with organic ligands, revealed a high degree of polymorphism, as well as crystalline polymorphs which were not previously identified probably due to the lack of adequate tools to characterize microcrystalline protein precipitates. The aim of this talk is to describe the frontier of powder diffraction as it begins to make a significant impact on structural biology. Issues which will be discussed include: (a) application of the molecular replacement technique and structure refinements of selected proteins associated with pharmaceutical interest (b) high throughput investigations such as crystal screening andphase diagram mapping and (c) ligand binding.


  • 22 April 2016: InnovCrete Seminar » How do proteins evolve? , IMBB-FORTH, Heraklion, Crete

  • Prof. Dan S. Tawfik, Weizmann Institute of Science, Israel
    Friday, April 22nd, 2016 @ 12:00
    FORTH Amphitheatre
    Host: M. Kokkinidis

    I will briefly describe our insights regarding how new enzymatic functions evolve, via gradual, small changes in sequence, and while preserving the overall structure (fold) and active-site architecture. However, the mechanisms underlying these evolutionary /micro-/transitions do not explain the /macro/ evolutionary transitions – how completely new folds emerge, let alone how the very first protein(s) evolve. The latter are thought to have emerged from short polypeptides. I will describe our findings with respect to how functional, globular proteins may emerge from short peptides.


  • 20 April 2016: InnovCrete Seminar » From Biological Self-Assembly to Novel Peptide Nanostructures of Unique Mechanical, Optical, Piezoelectric and Semiconductive Properties , IMBB-FORTH, Heraklion, Crete

  • Prof. Ehud Gazit, Tel Aviv University, ISRAEL
    Friday, April 20, 2016 @ 14:00
    FORTH Amphitheatre
    Host: M. Kokkinidis

    Bio-inspired nanotechnology is a key direction in the field of molecular self-assembly. Concept and notions from biological self-assembly allow the design and fabrication of nanomaterials, while molecular self-assembly paradigm could be applied to biological systems. Our works on the mechanism of aromatic peptide self-assembly, lead to the discovery that aromatic peptides, as short as dipeptides, self-assembles into peptide nanotubes with a remarkable physical properties We recently extended our studied to single amino acids and metabolites. We established the concept that even these entities can form well-ordered assemblies with amyloid like properties including ultrastructural morphology, toxicity leading to apoptosis, ThT-binding, and Congo-red birefringence.


  • 14 April 2016: Workshops » Regional Workshop on Research Funding opportunities, IMBB-FORTH, Heraklion, Crete

    • PPT File Introduction Prof. Michael Kokkinidis (IMBB-FORTH)
    • PPT File "Marie Curie Programs as a launch pad for research based mobility in Structural Biology" Artemis Saitakis, Director, STEP-C
    • PPT File H2020/SME Instrument : Time for exciting ventures in Structural Biology Maria Makridaki, HELP-FORWARD NETWORK/FORTH
    • PPT File “Health, demographic change and well-being- Call for proposals 2016-2017” Panagiotis Ignatiadis, HELP-FORWARD NETWORK/FORTH
    • PPT File European Innovation Partnership in Active Aging Panagiotis Ignatiadis, HELP-FORWARD NETWORK/FORTH
    • PPT File Closing the gap between research centers and SMEs : The H2020/ SME Innovation Associate Scheme Iraklis Karantonis, HELP-FORWARD NETWORK/FORTH
    PDF File Agenda

  • 29-30 October 2015: Workshops » Innovation Management & Awareness and Innovation Capacity Building, IMBB-FORTH, Heraklion, Crete

    • PDF File Welcome Address, M. Kokkinidis (IMBB-FORTH)
    • PDF File Prof. Yiannis Bakouros, University of W. Macedonia | "From Research Results to Innovative Products, Innovation Capacity Building" , "Innovation and Assets Management"
    • PDF File Artemis Saitakis, Director, Science & Technology Park of Crete| "Valuation and Negotiation of Intellectual Assets"
    • PDF File Artemis Saitakis, Director, Science & Technology Park of Crete| "IPR MANAGEMENT IN HORIZON 2020"
    • PDF File George Papamichail, Science & Technology Park of Crete | "Together for start-up"
    • PDF File Kostas Abatzis, Hellenic Industrial Property Organization | "Protection of bio inventions"
    • PDF File Kostas Abatzis, Hellenic Industrial Property Organization | "Intellectual Property Strategies"
    • PDF File Kostas Abatzis, Hellenic Industrial Property Organization Crete | "Searches for inventions in International Databases"
    • PDF File FORTH/ PRAXI Network | Enterprise European Network (EEN)
    The two workshops focus on one hand on identifying and securing IPR, IPR management, technology transfer and commercialization of research results, and on the other hand on building awareness about innovation and its impact in research organizations and SME’s, while providing an overview of Innovation Strategy (Why, Where and When to Innovate?) and Innovation Capacity (How to Innovate? With What People and Resources?).

    The workshops are organized in the framework of the EU/REGPOT project InnovCrete coordinated by Prof. M. Kokkinidis (IMBB/FORTH & UoC/Dept. of Biology).

    Please submit your registration using the attached forms by October 27th, 2015. The workshops will take place 29-30 October 2015 (final agenda is attached) at the Science and Technology Park of Crete (STEP-C), Building B, Meeting Room 211, 1st floor.

    Because the number of the participants to the workshopsis limited to 30, it is highly recommended that you send back the completed form a.s.a.p.

    Doc File Registration form, PDF File Agenda

  • 8 July 2015: Seminar » Anastasia Gazi, Type III secretion systems: four decades of research, IMBB-FORTH, Heraklion, Crete

  • Anastasia Gazi
    Lab. d’Enzymologie et Biochimie Structurales,
    CNRS, Gif-sur-Yvette, France
     
    Host: M. Kokkinidis
  • 16-18 February 2015: Workshop » BiosCrete2015: Acoustic & optical systems for studying biomolecular interactions, IMBB-FORTH, Heraklion, Crete
  • PDF File Program
  • 21 October 2014: An Information Day on the Research PPPs will take place on 21 October 2014 in Brussels. The aim of the event is to give the research community an overview of ongoing activities, and to support the preparation of proposals for the 2015 calls. The info day will also offer plenty of opportunities for networking.
  • More information
  • 19-21 September 2014: Current Trends in Structural Biology & 7th Meeting of the Hellenic Crystallography Association, IMBB-FORTH, Heraklion, Crete
  • Website, PDF File Poster
  • 30 June - 4 July 2014: ParaMet Summer School, Computational Sciences in Drug Discovery, FORTH Institute, Heraklion, Crete
  • PDF File Information
  • 29 May 2014: Seminar » P. Filippakopoulos, Targeting the Epigenetic Readout of Acetyl-Lysine, IMBB-FORTH, Heraklion, Crete

  • Panagiotis Filippakopoulos
    University Research Lecturer,
    Wellcome Trust Career Development Fellow
    Structural Genomics Consortium & Ludwig Institute of Cancer Research
    Nuffield Department of Clinical Medicine, University of Oxford
  • 31 March 2014: Workshop » Financial Instruments for Research Funding 2014-2020, IMBB-FORTH, Heraklion, Crete

  • PDF File Workshop Agenda
    PDF File Welcome Address, M. Kokkinidis (IMBB-FORTH)
    PDF File Horizon2020 financial instruments for research infrastructures, J. Taddei (European Commission, DG Research & Innovation, Brussels)
    PDF File Regional Innovation Strategy of Crete for the period 2014-2020, M. Kassotaki, Director, Intermed (Managing Authority, Region of Crete)
    PDF File Leveraging venture capital to bring projects from the lab to the market, G. Kasselakis (Openfund)
    PDF File Technology Transfer and exploitation of research results, A. Saitakis, Director (Science Technology Park of Crete)
  • 14 March 2014: Seminar » J. Kjems, The expanding family of non-coding RNAs -- increasing complexity of gene regulation and new opportunities in nano medicine

  • Jorgen Kjems
    Director of Interdisciplinary Nanoscience Center (iNANO)
    Director of Lundbeck Nanomedicine Center (LUNA)
    Interdisciplinary Nanoscience Center (iNANO)
    Department of Molecular Biology and Genetics Aarhus University, Denmark
  • 28 February 2014: Seminar » P. Pavlidis, Studying DNA to learn about evolutionary history... or to say fairy tales

  • 30-31 May 2013: InnovCrete Meeting, IMBB-FORTH, Heraklion, Crete
  • 18 December 2012: Open Event at FORTH
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